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Contact information Lawrence Livermore National Laboratory 7000 East Avenue, L-452 Livermore, CA 94550 email: murugesh2@llnl.gov phone: 925 422 6290 |
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Education
B.S., Molecular and Cell Biology, University of California, Berkeley, 1990
Research interests
Molecular Biology, Skeletal and Limb Development, Genetics of Osteoporosis and Osteoarthritis.
My research involves the use of transgenic and knockout mouse animal models to understand the molecular pathways that are important in Bone formation and remodeling
Publications
1. Collette NM, Yee CS, Murugesh D, Sebastian A, Taher L, Gale NW, Economides AN, Loots GG (2013) Sost and its paralog Sostdc1 coordinate digitnumber in a Gli3-dependent manner. Developmental Biology. 383(1):90-105.
2. Loots GG, Keller H, Leupin O, Murugesh D, Collette N, Genetos DC (2012) TGF-β regulates sclerostin expression via the ECR5 enhancer. Bone. 50(3):663-659.
3. Toupadakis CA, Wong A, Genetos DC, Chung DJ, Murugesh D, Anderson M, Loots GG, Christiansen BA, Kapatkin A, Yellowley CE. (2012) Long term administration of AMD3100, an antagonist of SDF-1/CXCR4 signaling alters fracture repair. J Orthoped Res. 30(11):1853-1859.
4. Taher L, Collette NM, Murugesh D, Maxwell E, Ovcharenko I, Loots GG. (2011) Global gene expression analysis of murine limb development. PLoS One. 6(12):e28358.
5. Collette NM, Genetos DC, Murugesh D, Harland RM, Loots GG. (2010) Genetic evidence that SOST inhibits WNT signaling in the limb. Dev Biology. 342(2):169-179.
6. Philip R, Clary B, Brunette E, Kilinski L, Murugesh D, Sorich M, Yau J, Lebkowski J, Lyerly HK, Philip M. (1996) Gene Modification of primary tumor cells for active immunotherapy of human breast and Ovarian Cancer. Clinical Cancer Research 2(1): 59-68.
7. Gong EL, Stoltfus LJ, Brion CM, Murugesh D, Rubin EM. (1996) Contrasting in vivo effects of murine and human apolipoprotein AII; Role of monomer versus dimer. J Biological Chemistry 271(11): 5984-7.
8. Philip R, Brunette E, Kilinski L, Murugesh D, McNally MA, Ucar K, Rosenblatt J, Okarma TB, Lebkowski JS. (1994) Efficient and sustained gene expression in primary T lymphocytes and primary and cultured tumor cells mediated by adeno-associated virus plasmid DNA complexed to cationic liposomes. Molecular Cell Biology 14(4): 2411-8
9. Bethel CA, Murugesh D, Harrison MR, Mohandas N, Rubin EM. (1993) Selective Erythroid replacement in murine beta-thalassemia using fetal hematopoietic stem cells. PNAS 90(21):10120-4