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Contact information Lawrence Livermore National Laboratory 7000 East Avenue, L-452 Livermore, CA 94550 email: coleman16@llnl.gov phone: 925 423 7687 |
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Education
Post-Doctoral Fellow, Lawrence Livermore National Laboratory, 1997-2000
Ph.D., Molecular Biochemistry and Cellular Biology, Boston University, 1997
B.S., Biology, University of Massachusetts, at Boston, 1987
Research interests
Radiobiology, molecular biology, biochemistry, and biodetection.
My group is pursuing research to identify the cellular mechanisms associated with ionizing radiation exposures. This work relies on using genomic and proteomic techniques to identify and characterize biological networks that regulate the responses to ionizing radiation. Such information can be utilized for developing diagnostic assays and tools for biodosimetry as well as the treatment and the prevention of cancer. I am also working on developing advance biochemical techniques using nanoparticles made of apolipoproteins and phospholipids called nanolipoproitein particles. These nanoparticles are useful for drug delivery, understanding receptor biochemistry and supporting structural biology of membrane proteins.
Projects
NIH-NCI-R01 – Characterization of HER2 family of proteins.
NIH-NCI-R01. – Optimizing 131I-miBG therapy for children with advance neuroblastoma.
Selected publications/Abstracts (5 most recent and 10 highlights related to science and technology)
Most recent publications/Abstracts:
1. Córdova, E. Martinez-Hernandez, A., Centeno, F., Uribe-Figueroa, L., Morales-Marin, M., Koneru, H., Coleman M.A., and Orozco, L. (2014) The Nrf2-Keap1 pathway is an early responsive gene network in arsenic exposed lymphoblastoid cells. PloS One. 9(2):e88059.
2. Ly, S., Bourguet, F.A., Fischer, N., Lau, E.Y. Coleman, M.A. and Laurence T.A. (2014) Quantifying membrane protein interactions in solution using fluorescence correlation spectroscopy. Biophysical Journal. 106:5-8
3. Straume, T., Loftus, D.J., Li, J., Coleman, M.A., Davis, C.E. McMonigal, K.A., Piccini, M. and Singh, A.K. Biomarker-Detection Technologies Suitable for Medical Diagnosis During Deep-Space Missions. (2013) Recent Progress in Space Technology. 3, 13-23.
4. Kim D., Marchetti, F., Chen, Z., Zaric, S., Wilson, R.J., Hall, D.A., Gaster, R.S., Lee, J., Wang, J., Osterfeld, S.J., Yu, H., White, R.M., Blakely, W.F., Peterson, L., Bhatnagar, S., Manion, B., Tseng, S., Roth, K., Coleman, M., Snijders, A., Wyrobek, A.J., and Wang S.H. Nanosensor dosimetry of mouse blood proteins after exposure to ionizing radiation. (2013) Nature/Scientific Reports. 19:2234.
5. He, W., Luo, J., Bourguet, F., Xing, L., Yi, S., Gao, T., Blanchette, C., Henderson, P., Kuhn, E. Malfatti, M., Murphy, W., Cheng, H., Lam, K., and Coleman, M.A. Controlling the Diameter, Monodispersity and Solubility of ApoA1 Nanolipoprotein Particles using Telodendrimer Chemistry. (2013) Protein Science 22, 1078–1086.
Related publications/Abstracts:
1. Budworth, H., Snijders, A.M., Marchetti, F., Mannion, B., Bhatnagar, S., Ely Kwoh, E., Tan, T., Blakely, W.F., Coleman, M.A., Peterson, L., and Wyrobek, A.J.. DNA repair and cell cycle biomarkers of radiation exposure and inflammation stress in human blood. (2012) PloS One. 7(11):e48619.
2. Gao, T., Petrlova, J., He, W., Huser, T., Kudlicki, W., Voss, J., and Coleman, M.A. Characterization of de novo synthesized GPCRs supported in nanolipoprotein discs. (2012) E.Pub, PloS One. 7(9):44911.
3. Bourguet, F.A. Souza, B.E., Hinz, A.K., Coleman M.A. and Jackson P.J. Characterization of a novel endolytic protein, AmpD BCZK2532 as a Bacillus anthracis antimicrobial protein. (2012) Appl Environ Microbiol. 78:3025-7.
4. Wyrobek, A.J., Manohar, C., Krishnan, K., Nelson, D. Marchetti, F.M. and Coleman, M.A. (2011). Low dose ionizing radiation responsive pathways in human lymphoblastoid cells. Mutation Research. 722: 119-130.
5. Martínez, A., Blanco, B., Carnevale, A., Mora, M.A., Coleman, M.A. Romero-Talamás, C.A. and Frías, S. (2010) Assessment of immediate DNA damage to workers occupationally exposed to low dose of ionizing radiation using the Comet Assay. J. of Clinical Investigation. 62:23-30.
6. Khnouf, R., Olivero, D., Jin, S., Coleman, M.A., Fan, Z.H. (2010) Fluidic Microplate for High-Throughput Protein Expression. Analytical chemistry. 82:7021-6.
7. Thompson, D., Pearson, F., Rao, R., Matthews, D. Albala, A., Wachsmann-Hogiu, S., and Coleman, M.A. (2009) A portable hand-held microarray reader for biodetection. Sensors. 9: 2524-2537.
8. Narayan, S., Lehmann, J., Coleman, M.A., Vaughan, A., Yang, C.C., Enepekides, D., Farwell, G., Purdy, J.A., Laredo, G. Nolan, K., Pearson, F. and Vijayakumar, S. (2008). Prospective evaluation to establish a dose response for clinical oral mucositis in patients undergoing head and neck conformal radiotherapy. Int J Radiat Oncol Biol Phys. 72:756-62.
9. Martinez, A., Hinz, J., Gomez, L., Molina, B., Acuna, H., Frias, S. and Coleman, M.A. (2008). Differential expression of TP53 associated genes in fanconi anemia cells after mitomycin C and hydroxyurea treatment. Mutat. Res. 656, 1-7.
10. Cappuccio, J.A., Blanchette, C.D., Sulchek, T., Arroyo, E. S. Hinz, A.K. Chromy, B.A. Fletcher, J., Katzen, F., Kudlicki, W., Bench, G., Hoeprich, P.D. and Coleman, M.A. (2008) Self-assembly of solubilized functional integral-membrane proteins in nanolipoprotein complexes using cell-free co-expression. Mol. Cell. Proteomics. 7, 2246-2253.